Platelet Rich Plasma Therapy

PRP Treatment for Fertility

PRP in reproductive medicine

1. PRP in premature ovarian failure

• Premature ovarian failure (POF) refers to loss of normal function of the ovaries before age 40, accompanied by the loss of fertility.
• PRP therapy is investigated in women with POF, infertile women more than 35 years of age, and women with low ovarian reserve. Treatment with PRP is referred to as ovarian rejuvenation; in this procedure, PRP is injected into the ovary under ultrasound guidance, similarly to ovum retrieval in in vitro fertilization (IVF).
• Patient with low ovarian reserve had PRP injected in the ovaries. PRP in perimenopausal/POF patients had ovarian rejuvenation 1–3 months after PRP treatment.

2. Repeated implantation failure

• Repeated implantation failure (RIF) is defined as failure to conceive following several embryo transfers in IVF cycles.
• Several methods have been suggested for RIF management, but little consensus exists on which is most effective. These methods include blastocyst transfer, assisted hatching, hysteroscopy, endometrial scratching, and immune therapy.
• Recently, the intrauterine infusion of PRP has been described as a way to promote endometrial growth and receptivity

PRP is an effective procedure improving pregnancy rate outcomes in RIF patients.

PRP Therapy in IVF

• This is an alternative therapy in case of chronic endometritis and endometriosis. These diseases can make implantation of the embryo is difficult in both IVF cycles and natural pregnancies. The PRP injection helps to prevent the inflammation process in the uterus and enhances the progesterone receptors activity which stimulates the growth of the endometrium and also helps to embryo inflammation. After this PRP therapy, it is possible to continue fertility treatment IVF with the best results.
• In case of ovarian failure syndrome, PRP method is strengthening the ovarian rejuvenation. If the PRP is injected into the ovaries of premenopausal or menopausal women, then the menstrual cycle is restarted which makes the possibility to collect the eggs from the woman’s ovaries and then fertilize the eggs that can be produced in woman’s ovaries.
• This technique can be helpful for women who have ovarian failure syndrome or advanced maternal age. PRP treatment is not an assisted reproduction method. It is an advanced technique for folliculogenesis restoration and menstrual cycle.

PRP Therapy Stages

• PRP therapy is carried out in a number of stages. Firstly 8 to 20 ml of blood is collected from the patient. Then is blood is placed in a centrifuged and divided into components. Leukocytes and red blood cells are removed from the blood. The platelets are now concentrated. This technique is allowing obtaining platelet rich plasma. The platelet concentration is 3 to 5 times higher than the blood.

Indications:

• People with poorly developed endometrium who cannot get the required level of endometrial thickness for embryo transfer.
• Chronic endometriosis and endometritis
• Premenopausal and menopausal women
• Recurrent IVF failure
• Ovarian failure syndrome

How safe is Platelet Rich Plasma Therapy?

• There are no side effects of PRP therapy. The Patient’s own blood is used for injection.
• The PRP injection will work differently for different women. So, it is difficult to say how many eggs released after PRP therapy which depends on the woman’s reproductive system.
• In any case, the single egg production of menopausal and premenopausal women when their ovaries are practically atrophied that could be a chance of getting pregnant with their own eggs which also increase clinical pregnancy rates.