Platelet Rich Plasma (PRP)
Platelet-rich plasma (PRP) is becoming more popular as a nonoperative treatment option for a broad spectrum of medical disorders. Autologous PRP is derived from an individual’s whole blood then centrifuged to remove red blood cells. The remaining plasma has a 5- to 10-fold higher concentration of growth Platelets than whole blood.
Platelets promote healing and attract stem cells to the site of the injury. Moving from basic science to clinical practice, PRP injections have been applied to the ENDOMETRIUM an OVARIES (OVARIAN REJUVENATION)
A) PRP in premature ovarian failure
Premature ovarian failure (POF) refers to loss of normal function of the ovaries before age 40, accompanied by the loss of fertility.
PRP therapy is investigated in women with POF, infertile women more than 35 years of age, and women with low ovarian reserve.
Treatment with PRP is referred to as ovarian rejuvenation; in this procedure, PRP is injected into the ovary under ultrasound guidance, similarly to ovum retrieval in in vitro fertilization (IVF) or via Laparoscopy
Patient with low ovarian reserve had PRP injected in the ovaries. PRP in perimenopausal/POF patients had ovarian rejuvenation 1–3 months after PRP treatment.
B) Repeated implantation failure
Repeated implantation failure (RIF) is defined as failure to conceive following several embryo transfers in IVF cycles. Recently, the intrauterine infusion of PRP has been described as a way to promote endometrial growth and receptivity. PRP is an effective procedure improving pregnancy outcomes in RIF patients.