A specialised kind of ICSI called intracytoplasmic morphologically chosen sperm injection (IMSI) selects sperm using a more powerful microscope. Using a microscope that can magnify the material up to 400 times, the embryologist uses standard ICSI to choose the motile sperm that appear the most normal. IMSI is an ICSI variant in which the sperm sample is magnified over 6000 times using a high power light microscope that has been augmented by digital imagery. The sperm with the most regularly formed nuclei are then chosen.
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