In Vitro Maturation (IVM)

In vitro maturation (IVM) is the technique of letting the contents of ovarian follicles and the oocytes inside mature in vitro(outside the body/in the LAB). It can be offered to women with infertility problems, combined with IVF, offering women pregnancy with or without ovarian stimulation. When a woman undergoes IVF, she usually takes medicine to cause more than 1 egg to mature at the same time. These eggs are collected before they are released from the ovary, and are then paced with sperm in the laboratory in hopes of fertilization. In some cases, some or all of the oocytes (eggs) that are collected are not mature and ready to be fertilized. Advances in science have allowed embryologists to take these immature eggs and sometimes “ripen” them in vitro (in the laboratory). This is called IVM. The eggs may be frozen for later use Or, they may be matured, fertilized, and placed into a woman’s uterus in hopes of pregnancy.

Are women undergoing IVM required to take injectable medicines to induce ovulation?

In IVM cycle, low-dose injectable medications are given. In recent clinical studies, low-dose ovarian stimulation for removal of immature eggs may yield more eggs and improve the lining of the uterus to receive the embryo.

Are there any benefits to IVM?

IVM requires less medication than conventional IVF and lowers the immediate cost of treatment; however, the pregnancy rates are also lower, so it is unclear whether IVM is more cost-effective.
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